The came into the season with high expectations after making the playoffs for the third straight year, but now they desperately need a win when they face the on Sunday Night Football. Injuries have been an i sue, and quarterback has been under constant pre sure and has thrown six interceptions. But Philadelphia (0-2-1) faces one of the few teams in the NFL with Dave Parker Jersey more injuries in the 49ers (2-1). took over for an injured last week as the 49ers beat the Giants while playing without 10 starters. The Eagles settled for a 23-23 tie with the .Kickoff for Sunday Night Football is set for 8:20 p.m. ET. William Hill has the 49ers listed as a 7.5-point favorite in the latest Eagles vs. 49ers odds, with the over-under for total points at 45. Before you lock in your 49ers vs. Eagles picks, you need to .A national sportswriter whose work appears in the New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. He prefers to evaluate each game from the underdog's point of view and has used that philosophy to dominate the NFL, going 66-44 against the spread in 2019 and 63-46 in 2018.Tierney entered the 2020 season with a 282-222 record at SportsLine (2016-19) on all , returning $3,704 to $100 players, and is 12-7 in his past 19 Tyler Glasnow Jersey NFL against-the-spread picks. He's also had a sharp eye for the tendencies of both the Eagles and 49ers, posting a 12-8 record on against-the-spread picks for or against Philadelphia and San Francisco. Anyone who has followed him is way up.Now, he's looked at from every po sible angle. You can . Here are the and trends for 49ers vs. Eagles: 49ers vs. Eagles spread: San Francisco -7.549ers vs. Eagles over-under: 45 49ers vs. Eagles money line: Philadelphia +290, San Francisco -350 PHI: QB Carson Wentz is second on the team with 74 rushing yards.SF: Rookie WR is averaging 12.2 yards on 10 touches this season. Why the 49ers can cover San Francisco is fourth in the league in yards allowed (304 per game) and has forced four turnovers, while the Eagles have given up a league-high eight. Linebacker remains the Kent Tekulve Jersey leader of the defense, posting one of the team's two interceptions and leading the unit with 28 tackles.The 49ers are 5-1 against the spread in their last six games as favorites, and Mullens threw for 343 yards in place of Garoppolo in a 36-9 win against the in Week 3. Garoppolo is likely out with a high ankle sprain, while tight end (knee) will return on Sunday Night Football. Brandon Aiyuk, the 25th overall pick in the 2020 draft, flashed big-play ability with 101 total yards against the Giants, including a 19-yard run and a 20-yard reception. Why Bryan Reynolds Jersey the Eagles can cover The Eagles are 9-4 against the spread in their last 13 games in October, and Wentz still has the talent that helped him throw for more than 4,000 yards and 27 touchdowns last season. He only threw seven picks last season, so the decision-making should improve, and the 49ers have just two interceptions this season. San Francisco also is allowing more than 116 rushing yards per game, so (238 total yards) should find a little room to operate. is Erik Gonzalez Jersey one of the few healthy receivers for the Eagles, who are 5-2 ATS in their last seven as a road underdog, and he is an elite option. He has a team-high 15 catches for 130 yards and a score. The defense is tied for third in the NFL with 12 sacks, led by with three and and with two apiece. The secondary also is strong, with safeties and combining for 33 tackles and Mills adding 1.5 sacks.How to make 49ers vs. Eagles picks We can tell you Tierney is leaning Under the total, and he's also found a critical X-factor that has him jumping all over one side of the spread. .So who wins Eagles vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? .